Best model organisms for chromatin studies

The first model organism whose chromatin I would start study is the Tetrahymena thermophila that satisifies the basic conditions of a good model organism, such as short life cycle, low cost, accesibility to both forward and reverse genetics. Furthermore being a low eukaryote (unicellular), it is an excellent model for studying the chromatin from both the evolutionary, development and qualitative-quantitative ratio aspect relative to the higher eukaryotes such as vertebrates. On the other hand the existence of two types of telomeric chromatin and the newly discovered Lia proteins associated chromatin makes it promising for new discoveries that would provide insight on the chromatin[1]. Tribolium castaneum or differently known as red flour beetle would be the second model organism I would choose to study the genetic expression and epigenetic mechanisms of the components of the chromatin such as histone and the DNA. The main reasons for this choice are its phenotypic plasticity, epigenetic effects controlling their gene expression such as temperature, diet etc, accessibility, low cost, the easy measurability of the trans-generational effects due to their morphogenetically different development stages, expression of the antimicrobial peptides due to the histone acetylation and are very practical for DNA methylation that directly affects the chromatin due to their high amount of euchromatin [2]. The last model organism I would use is Tetrodontidae or putterfish as a higher eukaryotic organism, sharing genome similarity with humans, having a pure DNA (low concentration of “junk DNA”) and exhibition of interesting chromatin phenomena such as chromatin elimination [3].

References

1.http://genesdev.cshlp.org/content/7/12b/2641.full.pdf retrieved from Google Resource on 06.03.2018

2.https://www.sciencedirect.com/science/article/pii/S0079610715000346 retrieved from Google Resource on 06.03.2018

3.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC430906/